Natural scienceBioinformaticsBioinformatics algorithmsAlignment algorithms

Substitution models

Substitution rates of amino acids

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Margaret Dayhoff constructed PAM250 matrix for rather divergent sequences and noticed, that asparagines are extremely mutable, especially comparing to tryptophan. Match all true possible explanations.

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Asparagine is very rare.

Tryptophan is pretty large, thus it is complicated to find a similar amino acid.

Tryptophan has a distinctive chemistry.

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