From Woof to SNP
In this project, you will create a pipeline for the identification of SNPs using NGS data. You will learn how to work with the NCBI Sequence Read Archive database, perform quality control of sequence data in FASTQ format, build alignments to reference genomes, and find SNPs with the IGV genome browser.
Edvancium
About
Like humans, dogs can be predisposed to various diseases, for example, Degenerative Myelopathy. One of your friends recently learned about this disease and wants to know if their Welsh Corgi dog is at risk. You are tasked with helping to investigate whether there is a variation in the dog's genome associated with this predisposition. The replacement of just one nucleotide in the DNA chain is called single-nucleotide polymorphism (SNP). Such variations affect disease development, pathogen response, and visual and physiological features, moreover, they are the markers of other genetic mutations. In this project, you will create a pipeline for the identification of SNPs, associated with such a fatal disorder for Welsh Corgi.
Training project
This project allows you to practice and strengthen your coding skills, helping you get ready for more advanced tasks ahead.
What you'll learn
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